(-)-Carvone Inhibits Oxytocin-induced Writhing Via Uterine Relaxation in Rodents

The potency of (-)-carvone in reducing uterine contractions was significant, achieving an effectiveness of 92.63 ± 1.90% at a concentration of 10 µM in response to carbachol.

• Isolated virgin rat uterus experiments demonstrated that (-)-carvone has a spasmolytic effect on induced tonic contractions.
• The effectiveness of (-)-carvone was notably higher in carbachol and oxytocin-induced contractions compared to other agents.
• A significant reduction in writhing was observed in mice pre-treated with (-)-carvone at a dose of 100 mg/kg after oxytocin administration.
• No toxic effects were noted from oral administration of up to 1 g/kg of (-)-carvone.
• The action of (-)-carvone appears to involve potassium channels and the nitric oxide pathway.

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