Oversleepers have a 5.561 times greater risk of developing delirium compared to those with normal sleep duration.
Evening is associated with a higher risk of delirium, with an odds ratio of 1.879.
Waking up in the morning appears to reduce the risk of delirium, with an odds ratio of 0.544.
Daytime napping is linked to an increased risk of delirium, showing an odds ratio of 10.427.
Patients with delirium are more likely to have a morning chronotype, indicated by an odds ratio of 0.998.
Sensitivity analyses confirmed the robustness of these findings across various sleep characteristics.
Simplified
Delirium is a common neurological complication among hospitalized patients and has been closely linked to sleep disturbances. Dynamic changes in sleep rhythms are influenced by various sleep characteristics, which complicates the identification of the relationship between individual sleep features and the risk of delirium. Therefore, this study aimed to assess the potential causal relationships between distinct sleep characteristics and delirium, and to further investigate their independent effects. We obtained summary-level data on delirium and 10 distinct sleep characteristics. inverse-variance weighted (IVW) was employed as the primary analytical approach, supplemented by additional robust (MR) techniques. To ensure the robustness of the IVW results, heterogeneity tests and horizontal pleiotropy analyses were performed. Additionally, we employed a multivariable MR analysis to identify a direct causal relationship between the 2 conditions. The 2-sample MR analysis revealed that sleep duration (oversleepers) (OR = 5.561, 95% CI = 2.102-14.717, P < .001) and evening (OR = 1.879, 95% CI = 1.179-2.994, P = .008) were significantly associated with an increased risk of delirium. Conversely, getting up in the morning (OR = 0.544, 95% CI = 0.296-0.999, P = .049) and daytime dozing (OR = 0.134, 95% CI = 0.030-0.598, P = .008) appeared to be protective factors against delirium. The results of the reverse MR analysis showed that patients with delirium were more likely to exhibit a morning chronotype (OR = 0.998, 95% CI = 0.996-1.000, P < .020). Sensitivity analyses confirmed the robustness of the findings. Multivariable MR analysis further confirmed that evening chronotype remained causally associated with an elevated risk of delirium (OR = 3.860, 95% CI = 1.173-12.696, P = .026). Additionally, after adjusting for other sleep characteristics, daytime napping emerged as a significant risk factor for delirium (OR = 10.427, 95% CI = 1.246-87.287, P = .031). Various sleep characteristics exhibited both protective and detrimental effects on the risk of delirium. This study enhances our understanding of modifiable risk factors for delirium and offers new perspectives for its prevention strategies.
Key numbers
5.561
Increase in Risk (Oversleepers)
Odds ratio for delirium in oversleepers.
1.879
Increase in Risk (Evening )
Odds ratio for delirium in individuals with evening .
0.544
Decrease in Risk (Getting Up in Morning)
Odds ratio for delirium in those who find it easy to wake up.
Full Text
We can’t show the full text here under this license.
