The Ccr4-Not Protein Complex Regulates the Phase of the Neurospora Circadian Clock by Controlling WHITE COLLAR Protein Stability and Activity

Not1 is a key protein that influences the levels of the white collar complex, which is critical for circadian rhythm regulation in Neurospora.

• The not1 transcript shows a circadian oscillation that aligns with the timing of frq transcription.
• Reducing not1 levels leads to decreased amounts of WC-1 and WC-2 proteins, resulting in a delayed circadian phase.
• Increased protein degradation and heightened WC activity are observed with down-regulation of not1.
• Not1 is part of the Ccr4-Not complex, which is involved in regulating the circadian clock.
• Down-regulation of ccr4 causes a delay in the circadian phase and lengthens the clock period.

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