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Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock
RCO-1's role in controlling certain gene activity is essential for Neurospora's internal clock
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Abstract
RCO-1 is essential for clock function by regulating frq transcription.
- In rco-1 mutants, both overt and molecular circadian rhythms are abolished.
- frq mRNA levels remain constantly high in rco-1 mutants, indicating a disruption in normal regulation.
- Binding of the WHITE COLLAR (WC) complex to the frq promoter is significantly reduced in the absence of RCO-1.
- RCO-1 is shown to suppress WC-independent transcription of frq.
- Normal chromatin structure at the frq locus is maintained by RCO-1.
- Deletion of specific chromatin-related factors leads to WC-independent frq transcription and loss of rhythms.
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