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Cell-autonomous clock of astrocytes drives circadian behavior in mammals
Internal daily clocks in brain support cells help control daily behavior in mammals
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Abstract
The astrocytic clock can independently drive circadian behavior in mice.
- Cell type-specific transcription-translation negative feedback loops (TTFLs) were identified in neurons and astrocytes of the suprachiasmatic nucleus (SCN).
- In the absence of other cellular clocks, the astrocytic TTFL can still drive molecular oscillations within the SCN.
- Astrocytes influence the circadian function of SCN neurons through glutamatergic signals.
- Findings suggest that astrocytes are capable of autonomously initiating and sustaining complex behaviors in mammals.
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