Full text is available at the source.
Cell-intrinsic, Bmal1-dependent Circadian Regulation of Temozolomide Sensitivity in Glioblastoma
Internal Circadian Clock Gene Bmal1 May Affect Glioblastoma's Sensitivity to Temozolomide
AI simplified
Abstract
Daily rhythms in glioblastoma cells influence the effectiveness of the chemotherapy drug temozolomide (TMZ).
- Circadian rhythms were observed in both human and mouse glioblastoma cells.
- The timing of TMZ administration affected the sensitivity of murine GBM tumor cells to the drug.
- The greatest DNA damage, activation of cell death, and growth inhibition occurred when TMZ was given near the peak expression of the core clock gene Bmal1.
- Deleting the Bmal1 gene eliminated circadian rhythms in gene expression and reduced the effectiveness of TMZ.
- These findings suggest that the natural daily rhythms in tumor cells may influence chemotherapy outcomes.
AI simplified