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FoxM1 Inhibition Sensitizes Resistant Glioblastoma Cells to Temozolomide by Downregulating the Expression of DNA-Repair Gene Rad51
Blocking FoxM1 makes resistant glioblastoma cells more sensitive to temozolomide by lowering DNA repair gene Rad51
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Abstract
Recurrent glioblastoma multiforme tumors that were resistant to temozolomide (TMZ) expressed higher levels of FoxM1 than primary tumors.
- Recurrent GBM cell lines showed increased expression of FoxM1 and the DNA damage repair gene Rad51, correlating with TMZ resistance.
- TMZ treatment resulted in elevated levels of both FoxM1 and Rad51 in GBM cells.
- Knocking down FoxM1 reduced Rad51 expression and made recurrent GBM cells more susceptible to TMZ.
- FoxM1 was found to directly regulate Rad51 expression through specific binding sites in its promoter.
- A direct correlation between FoxM1 and Rad51 expression was observed in tumor samples from recurrent GBM patients.
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