The CXCL12/CXCR4 axis confers temozolomide resistance to human glioblastoma cells via up-regulation of FOXM1

Apr 26, 2020Journal of the neurological sciences

The CXCL12/CXCR4 pathway may cause resistance to temozolomide in human glioblastoma cells by increasing FOXM1 levels

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Abstract

The CXCL12/CXCR4 axis enhances temozolomide resistance in glioblastoma cells.

  • CXCL12/CXCR4 is associated with increased drug resistance in glioblastoma multiforme (GBM).
  • This axis promotes cell migration and invasion in GBM cells.
  • FOXM1 is up-regulated by CXCL12/CXCR4, contributing to TMZ resistance.
  • Suppressing CXCL12/CXCR4 and silencing FOXM1 partially reverses drug resistance.

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