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Exosomal transfer of miR-151a enhances chemosensitivity to temozolomide in drug-resistant glioblastoma
Small RNA carried in cell particles may increase drug sensitivity in treatment-resistant brain cancer
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Abstract
Exosomal miR-151a levels may predict chemotherapy response in glioblastoma multiforme (GBM).
- Chemoresistance reduces the effectiveness of Temozolomide (TMZ) in treating GBM.
- Loss of miR-151a is linked to the acquisition of TMZ resistance in GBM cells.
- Restoring miR-151a expression in TMZ-resistant cells enhances their sensitivity to TMZ by inhibiting DNA repair mechanisms.
- Exosomes from TMZ-resistant cells can transfer chemoresistance to sensitive GBM cells, dependent on the loss of miR-151a.
- CSF-derived exosomes reflect the chemoresistant status of GBMs by showing altered miR-151a expression levels.
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