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Abstract
Cellular senescence is linked to various age-related musculoskeletal diseases.
- Aging often results in reduced mobility and increased frailty due to diminished musculoskeletal function.
- Cellular senescence contributes to osteoporosis, osteoarthritis, intervertebral disc degeneration, and sarcopenia.
- Impaired regenerative capacity of stem cells and a pro-inflammatory environment are associated with the harmful effects of senescence.
- The senescence-associated secretory phenotype (SASP) can induce senescence in nearby cells, potentially worsening the condition.
- While removing senescent cells and suppressing SASP factors has shown potential in mouse models, significant efficacy has not yet been confirmed in clinical trials.
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