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Abstract
Therapeutic plasma exchange (TPE) may remove inflammatory cytokines and senescence-associated proteins, potentially improving healthspan.
- Cellular senescence and chronic inflammation are significant factors in aging.
- The senescence-associated secretory phenotype (SASP) contributes to age-related diseases, including cardiovascular disease, neurodegeneration, and cancer.
- Current anti-aging strategies, such as senolytics and SASP inhibitors, have limitations.
- TPE is proposed to reduce systemic inflammation while replenishing rejuvenating factors.
- Selective apheresis may enhance treatment precision by targeting specific components of the SASP.
- These interventions could improve immune function and tissue regeneration.
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