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The Yin and Yang of cellular senescence in ischemia-induced myocardial injury
The balancing roles of cell aging in heart damage caused by reduced blood flow
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Abstract
Cellular senescence is associated with both detrimental and potentially protective effects following myocardial infarction.
- Cellular senescence impacts aging, ischemia reperfusion injury, and age-related cardiovascular diseases.
- Cardiac senescent cells can promote inflammation, remodeling, and fibrosis, which may lead to functional decline after myocardial infarction.
- Evidence suggests that senescence may also limit fibrosis after myocardial infarction.
- Understanding the mechanisms of cardiac senescence could help identify new therapeutic targets for improving recovery after myocardial infarction.
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