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Signs of Cell Aging in Long COVID Compared to Other Post-COVID Conditions Using Gene Activity Analysis
Updated
Abstract
Senescence-associated genes were significantly upregulated in individuals who developed Long COVID symptoms, with a normalized enrichment score of 6.04.
- 56 individuals who developed Long COVID symptoms showed significant upregulation of senescence-associated genes compared to 104 who did not.
- Cognitive impairment was associated with an upregulation of these genes in 32 individuals compared to 40 without cognitive impairment.
- Persistent dyspnea was linked to a significant increase in senescence gene expression in 26 participants compared to 53 without persistent dyspnea.
- ETS2 was consistently upregulated across all impairment-related symptoms, while other senescence genes varied by phenotype.
- Findings indicate potential shared and unique patterns of gene expression related to Long COVID across different symptom types.
Simplified
Long Covid