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Abstract
Cellular senescence may contribute to aging through both internal and external mechanisms.
- Cellular senescence is associated with aging and may play a role in the decline of organismal function.
- The senescence-associated secretory phenotype is likely a significant factor in the effects of cellular senescence.
- Somatic DNA mutations show a strong correlation with aging.
- Determining the causal role of DNA mutations in age-related functional decline is complex due to their connection with initial genotoxic events.
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