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Abstract
Cellular senescence is associated with mechanical alterations, including changes in viscous properties.
- Cellular senescence involves a permanent halt in the cell cycle, which is linked to changes in mechanical properties.
- While stiffness and elasticity have been extensively studied, the viscous component of cellular mechanics remains largely unexplored.
- Changes in viscous properties may offer critical insights into cellular states, particularly regarding senescence and aging.
- Key factors influencing viscous properties during senescence include cytoskeletal remodeling, macromolecular crowding, and intracellular phase separation.
- Cellular viscous properties could serve as biomarkers for senescence, with potential applications in detection, aging assessment, and senolytic therapies.
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