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Cerebrospinal fluid metabolomic and proteomic characterization of neurologic post-acute sequelae of SARS-CoV-2 infection
Chemical and protein changes in spinal fluid linked to long-term brain symptoms after COVID-19
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Abstract
Proteomic and metabolomic analyses of cerebrospinal fluid from 21 neuro-PASC patients revealed 69 differentially expressed metabolites and six proteins compared to healthy individuals.
- Elevated sphinganine and ST1A1, along with a disorder in sphingolipid metabolism, may contribute to neuro-PASC.
- Attenuated inflammatory responses could also be involved in the occurrence of neuro-PASC.
- Decreased levels of 7,8-dihydropterin and increased steroid hormone biosynthesis may aid in the repair process.
- A biomarker cohort including sphinganine, 7,8-dihydroneopterin, and ST1A1 may have diagnostic value for neuro-PASC.
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