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Chemical Design Strategy of Ionizable Lipids for In Vivo mRNA Delivery
Designing Ionizable Lipids to Improve mRNA Delivery Inside Living Organisms
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Abstract
Lipid nanoparticles (LNPs) are the most clinically successful drug delivery systems for mRNA drugs and vaccines.
- Ionizable lipids (ILs) are critical components that influence the effectiveness of LNPs for delivering mRNA in living organisms.
- ILs consist of three parts: ionizable heads, linkers, and hydrophobic tails, allowing for diverse chemical structures.
- Combining different functional groups in ILs may lead to varied biological identities and enhance delivery performance.
- A summary of chemical design strategies for effective IL candidates is provided, focusing on their structure-activity relationships.
- Next-generation ILs are anticipated to improve tissue-selective mRNA delivery and facilitate broader applications of mRNA therapies.
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