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Abstract
Chronic pain, sleep disturbances, and mental health disorders are interconnected, forming a self-reinforcing cycle that significantly affects quality of life.
- Chronic pain is influenced by both peripheral and central sensitization.
- Central sensitization is sustained by interactions between microglia and astrocytes, along with maladaptive changes in the brain.
- Poor sleep can worsen pain through increased inflammation and disruption of circadian rhythms.
- Imbalances in neurotransmitters like serotonin, dopamine, and norepinephrine may contribute to anxiety and depression disorders.
- Elevated levels of pro-inflammatory cytokines and neuroinflammation are linked to these chronic conditions.
- Targeting inflammatory processes and neurotransmitter imbalances could provide therapeutic benefits for these interrelated disorders.
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