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Chronic pistachio intake modulates circulating microRNAs related to glucose metabolism and insulin resistance in prediabetic subjects
Regular pistachio eating changes blood molecules linked to sugar use and insulin resistance in people with prediabetes
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Abstract
Chronic pistachio consumption results in significantly lower circulating levels of miR-192 and miR-375 in individuals with prediabetes.
- A randomized crossover trial involving 49 subjects with prediabetes assessed the impact of a pistachio-enriched diet.
- After following a pistachio-supplemented diet, subjects showed lower levels of miR-192 and miR-375 compared to a control diet.
- Changes in the levels of miR-192 and miR-375 were positively correlated with plasma glucose, insulin, and insulin resistance measures.
- The increase in miR-21 after the pistachio diet was not statistically significant.
- The findings suggest that consuming pistachios may positively influence the expression of certain microRNAs associated with insulin sensitivity.
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