We can’t show the full text here under this license. Use the link below to read it at the source.
Chronic Sleep Fragmentation Differentially Affects Alzheimer’s Disease Pathology in Male and Female APPSAA Knock-in Mice
Ongoing Sleep Interruptions Affect Alzheimer’s Disease Changes Differently in Male and Female APPSAA Mice
AI simplified
Abstract
Sleep fragmentation increased pro-inflammatory cytokines by 40% in both male and female APPknock-in mice.
- disrupted sleep patterns, reducing light-phase sleep and increasing variability in both sexes.
- Increased astrocyte activation, indicated by higher GFAP levels, was observed, especially in females.
- Male mice exhibited decreased expression of microglial activation markers despite increased inflammation.
- Distinct regional and sex-specific patterns of accumulation were noted, with females showing higher levels in the neocortex.
- Medium-sized plaque density in the hippocampus was greater in females after sleep fragmentation, while males showed reduced amyloid-beta in certain fractions.
AI simplified
Key numbers
52.2%
Increase in GFAP Immunoreactivity
Measured increase in GFAP-positive area in the neocortex of sleep-fragmented females.
p = 0.001
Increase in Aβ Levels in Females
Statistical significance of PBS-soluble Aβ increase in female neocortex.
p = 0.017
Decrease in Detergent-Soluble Aβ in Males
Statistical significance of Aβ decrease in the neocortex of male mice.