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Glial cytokine modulation improves sleep and circadian disruption in female SAA knock‐in mice of Alzheimer's‐related pathology
Changing immune signals in support cells improves sleep and daily rhythms in female mice with Alzheimer's-related changes
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Abstract
Only females showed midlife reductions in light-phase sleep and increased rhythm fragmentation from 2 to 19 months.
- Sleep and circadian disturbances were observed in female mice with Alzheimer's-like features, while male mice did not exhibit the same changes.
- Increased rhythm fragmentation and reduced rhythm stability were linked to selective reversal learning deficits in female mice.
- Treatment with MW151 resulted in increased light-phase sleep and decreased levels of a specific inflammatory marker (TNF-α) in the cortex of aged female mice.
- The effects of MW151 on sleep were independent of changes in amyloid beta accumulation.
- Findings suggest that neuroinflammatory signaling may be a modifiable factor influencing sleep disturbances associated with Alzheimer's disease.
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