Changing immune signals in support cells improves sleep and daily rhythms in female mice with Alzheimer's-related changes

Only females showed midlife reductions in light-phase sleep and increased rhythm fragmentation from 2 to 19 months.

• Sleep and circadian disturbances were observed in female mice with Alzheimer's-like features, while male mice did not exhibit the same changes.
• Increased rhythm fragmentation and reduced rhythm stability were linked to selective reversal learning deficits in female mice.
• Treatment with MW151 resulted in increased light-phase sleep and decreased levels of a specific inflammatory marker (TNF-α) in the cortex of aged female mice.
• The effects of MW151 on sleep were independent of changes in amyloid beta accumulation.
• Findings suggest that neuroinflammatory signaling may be a modifiable factor influencing sleep disturbances associated with Alzheimer's disease.

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