Effects of chrononutrition on aging and lifespan

May 12, 2026Food research international (Ottawa, Ont.)

How Timing of Eating Affects Aging and Lifespan

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Abstract

Time-restricted eating within a 4-12 hour window may improve cardiometabolic health and healthspan metrics.

  • Alternate-day fasting and the 5:2 diet also show potential benefits for health and longevity based on various studies.
  • Observational studies indicate a U-shaped relationship between eating window duration and mortality risk, with an increased risk associated with ≤8 hour windows.
  • Aligning nutrient intake—such as carbohydrates, proteins, and antioxidants—with the body's natural circadian rhythms may further enhance health.
  • Irregular meal patterns, skipping breakfast, late-night eating, and frequent meals are linked to aging-related diseases and increased mortality risk.
  • Circadian clocks, nutrient-sensing pathways, and gut microbiota may play roles in how feeding patterns affect health outcomes.

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