Chronotherapy With Nifedipine GITS in Hypertensive Patients: Improved Efficacy and Safety With Bedtime Dosing

Bedtime dosing of nifedipine led to a significant reduction in blood pressure, especially during night time sleep.

• Blood pressure reduction was significantly larger with bedtime dosing compared to morning dosing (P < 0.012).
• More patients achieved controlled ambulatory blood pressure with bedtime treatment than with morning treatment (P = 0.016).
• The prevalence of nondipping blood pressure patterns decreased from 51% to 35% with bedtime dosing (P = 0.025).
• The morning surge of blood pressure was significantly reduced only after bedtime administration (P < 0.001).
• The incidence of edema dropped from 13% to 1% with bedtime dosing compared to morning ingestion (P < 0.001).

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