We canât show the full text here under this license. Use the link below to read it at the source.
Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism
Separating daily body clock and behavior effects on human metabolite rhythms reveals how body organs keep time and manage metabolism
AI simplified
Abstract
Nearly 95% of metabolites with a 24-h rhythmicity were influenced by external behavioral time cues during a simulated night-shift schedule.
- Misaligned sleep/wake and feeding/fasting cycles may disturb peripheral clock functions.
- A total of 132 circulating metabolites were analyzed for rhythmicity during a 24-h constant routine.
- Approximately half of the metabolites exhibited 24-h rhythmicity under constant routine after both simulated shift schedules.
- Traditional circadian markers such as melatonin and cortisol maintained stable phase alignment regardless of shift schedule.
- Many metabolites showed altered rhythms, including reversed rhythms or loss of rhythmicity, particularly after the night-shift schedule.
AI simplified
Key numbers
65 of 132
with 24-h rhythmicity
Significant rhythmicity observed during constant routine after simulated shift work.
3
Stable rhythmic
Serotonin, taurine, and maintained rhythms after both day and night shifts.