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Circadian clock and cancer: From a viewpoint of cellular differentiation
The Body’s Internal Clock and Cancer: How Cell Maturity May Be Involved
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Abstract
Circadian clock dysfunction may be linked to dedifferentiation and cancer development.
- The circadian clock regulates various physiological and behavioral processes aligned with Earth's 24-hour cycle.
- Most cells exhibit circadian patterns in gene expression, with the master regulator located in the hypothalamic suprachiasmatic nucleus.
- Embryonic stem cells and induced pluripotent stem cells do not demonstrate circadian oscillations until they differentiate.
- The emergence of the circadian clock during development is closely tied to cellular differentiation.
- Certain cancer cell types also lack a functional circadian clock, suggesting a potential connection to cancer biology.
- Circadian rhythm abnormalities may be associated with various diseases, including cancer, highlighting the need for further research.
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