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Human Circadian Molecular Oscillation Development Using Induced Pluripotent Stem Cells
Development of Daily Molecular Rhythms in Human Cells Made from Stem Cells
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Abstract
Human induced pluripotent stem cells (iPSCs) show no discernible circadian molecular oscillation.
- The development of the circadian clock in humans may involve mechanisms similar to those observed in mice.
- In vitro differentiation of human iPSCs requires a longer time than mouse cells for circadian oscillations to emerge.
- CLOCK protein expression in undifferentiated human iPSCs is posttranscriptionally suppressed, despite mRNA being present.
- This posttranscriptional suppression of CLOCK protein is consistent with findings in mouse embryonic stem cells and early embryos.
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