Journal of biological rhythms

Development of Daily Molecular Rhythms in Human Cells Made from Stem Cells

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Abstract

Human induced pluripotent stem cells (iPSCs) show no discernible circadian molecular oscillation.

  • The development of the circadian clock in humans may involve mechanisms similar to those observed in mice.
  • In vitro differentiation of human iPSCs requires a longer time than mouse cells for circadian oscillations to emerge.
  • CLOCK protein expression in undifferentiated human iPSCs is posttranscriptionally suppressed, despite mRNA being present.
  • This posttranscriptional suppression of CLOCK protein is consistent with findings in mouse embryonic stem cells and early embryos.

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Funding

Competing interests

Conflict of Interest Statement: The authors have no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
PubMed

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