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Development of the Circadian Core Machinery in Mammals
Development of the Internal Biological Clock System in Mammals
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Abstract
Circadian molecular oscillation develops gradually during mammalian development.
- Pluripotent stem cell differentiation cultures mimic the gradual emergence of circadian rhythms.
- Reprogramming cells to an undifferentiated state reverses the development of circadian oscillations.
- The circadian clock is closely linked to the differentiation state of cells.
- Nonrhythmic cells may exhibit different characteristics in circadian core machinery compared to rhythmic cells.
- Molecular mechanisms that suppress circadian oscillations are present during early development and in pluripotent stem cells.
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