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Disruption of circadian clockwork in in vivo reprogramming‐induced mouse kidney tumors
Disrupted daily biological rhythms in mouse kidney tumors caused by cell reprogramming
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Abstract
Circadian molecular oscillation is disrupted in dysdifferentiation-mediated mouse kidney tumors resembling Wilms tumors.
- Misregulation of cellular differentiation in mouse embryonic stem cells led to abnormal cell development and impaired circadian clock activity.
- A significant reduction in CLOCK protein levels was observed in tumor cells, despite normal levels of CLOCK mRNA.
- Similar loss of CLOCK protein was also found in human Wilms tumors.
- These findings indicate a potential link between disrupted circadian clock function and the development of embryonal tumors.
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