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Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice
Unusual daily rhythm gene activity in the liver and kidneys of mice on a long-term high-fat diet
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Abstract
Alterations in the expressions of circadian-clock genes were observed in the livers and/or kidneys of male C57BL/6 mice after 11 months on a high-fat diet.
- Obesity induced by a high-fat diet is associated with changes in circadian rhythms.
- The expressions of circadian-clock genes, including Per1-3, Cry1-2, Bmal1, Dbp, E4BP4, and CK1varepsilon, may be affected by obesity.
- Circadian clock-controlled genes such as PEPCK, PDK4, and NHE3 also show altered expression in relation to obesity.
- These findings suggest a link between metabolic syndrome and the regulation of circadian-clock genes.
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