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High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
High-fat diet alters daily behavior and internal body clocks in mice
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Abstract
A high-fat diet in mice alters the function of the mammalian circadian clock.
- Changes in the period of locomotor activity rhythm were observed following a high-fat diet.
- High-fat diet consumption led to alterations in the expression and cycling of key circadian clock genes.
- Nuclear receptors that regulate clock transcription factors were affected by dietary changes.
- Clock-controlled genes involved in fuel utilization in the hypothalamus, liver, and adipose tissue were also altered.
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