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High-fat diet and fasting may disrupt daily rhythms of fat-related signals in muscle and fat tissue
Updated
Abstract
Under a low-fat diet, adiponectin signaling pathway components showed circadian rhythmicity at the mRNA levels.
- Disruption of circadian rhythms may lead to obesity and metabolic disorders.
- Fasting and a high-fat diet resulted in altered circadian expression patterns of adiponectin pathway components in mice.
- Specific changes in expression levels of adiponectin receptors and metabolic regulators were observed under different dietary conditions.
- Both PPARalpha and AMPK may play a role in mediating the disruptions in clock gene expression associated with a high-fat diet.
- The circadian clock is linked to the daily rhythm of adiponectin signaling components.
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