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High-Fat Diet Delays and Fasting Advances the Circadian Expression of Adiponectin Signaling Components in Mouse Liver
High-fat diet slows and fasting speeds up daily timing of fat-signaling genes in mouse liver
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Abstract
Adiponectin signaling pathway components in the liver exhibit circadian rhythmicity under a low-fat diet.
- Fasting and high-fat diet disrupt the circadian expression of adiponectin signaling pathway components.
- Fasting leads to a phase advance in the circadian expression of these components.
- High-fat diet causes a phase delay in the circadian expression of adiponectin signaling pathway components.
- Adenosine monophosphate-activated protein kinase levels are elevated during fasting and reduced during high-fat diet.
- Alterations in the circadian rhythm of clock genes and adiponectin signaling may be linked to obesity and metabolic disorders.
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