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Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver
Daily protein rhythms controlled by the body clock and other factors support different daytime functions in mouse liver
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Abstract
Over 5,000 proteins were identified in the murine liver, with several hundred exhibiting robust diurnal oscillations.
- Diurnal oscillations in protein levels peaked in the morning and night, correlating with core liver functions.
- Proteins showed reduced amplitudes and significant delays in accumulation compared to their mRNA counterparts.
- Approximately half of the rhythmic proteins did not have corresponding rhythmic mRNAs, suggesting additional control mechanisms at the protein level.
- Secreted proteins demonstrated pronounced accumulation patterns during the night.
- Rhythmic patterns persisted in clock-deficient mice when subjected to rhythmic feeding, indicating that feeding cues may regulate these rhythms.
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