Proceedings of the National Academy of Sciences of the United States of America

Daily protein rhythms controlled by the body clock and other factors support different daytime functions in mouse liver

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Abstract

Over 5,000 proteins were identified in the murine liver, with several hundred exhibiting robust diurnal oscillations.

  • Diurnal oscillations in protein levels peaked in the morning and night, correlating with core liver functions.
  • Proteins showed reduced amplitudes and significant delays in accumulation compared to their mRNA counterparts.
  • Approximately half of the rhythmic proteins did not have corresponding rhythmic mRNAs, suggesting additional control mechanisms at the protein level.
  • Secreted proteins demonstrated pronounced accumulation patterns during the night.
  • Rhythmic patterns persisted in clock-deficient mice when subjected to rhythmic feeding, indicating that feeding cues may regulate these rhythms.

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Competing interests

The authors declare no conflict of interest.
PubMed

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