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Circadian Clock Regulates Epidermal Endocrine System in Homeostatic Skin Pigmentation
The Body’s Internal Clock Controls Skin Hormones That Maintain Normal Skin Color
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Abstract
Silencing the core circadian clock genes BMAL1 and CLOCK significantly reduced melanin synthesis in human melanocytes.
- Knockdown of BMAL1 or CLOCK altered the expression of hormone-related factors involved in melanogenesis.
- The vitamin D-metabolizing enzyme CYP27A1 showed a marked decrease in expression following silencing of either gene.
- Reduced CYP27A1 expression was also observed in melanocytes within vitiligo lesions.
- Disruption of circadian regulators is associated with impaired melanin production and changes in vitamin D metabolism.
- These findings highlight a potential link between circadian regulation and pigmentation disorders.
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