The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration

The proliferation of the intestinal epithelium follows a 24-hour rhythm during the gastrointestinal syndrome.

• The circadian clock remains active in the intestinal epithelium even during gastrointestinal syndrome.
• Disruption of the core clock gene impairs both the circadian rhythm and the proliferation of intestinal cells.
• Circadian activity in the intestine is linked to rhythmic production of inflammatory signaling molecules.
• There is a rhythmic activation of the JNK stress response pathway associated with these inflammatory processes.
• Understanding the timing of these processes may be important for the study and treatment of radiation-induced gastrointestinal illnesses.

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