Down-Regulation of Circadian Clock Gene Period 2 in Uterine Endometrial Stromal Cells of Pregnant Rats During Decidualization

Dec 25, 2010Chronobiology international

Lower activity of the daily rhythm gene Period 2 in uterine support cells during early pregnancy in rats

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Abstract

Per2 oscillation was observed to have a period of approximately 24 hours in uterine endometrial stromal cells during implantation.

  • Per2 oscillation was enhanced in uterine endometrial stromal cells during implantation but attenuated during decidualization.
  • In vivo studies indicated that PER2 protein levels in the uterus peaked at zeitgeber time 4 and trough at zeitgeber time 12 on day 4.50 of gestation.
  • No significant circadian rhythm of PER2 protein was found during the decidualization phase.
  • Circadian rhythms in Vegf gene expression were noted during implantation, with peaks at zeitgeber time 0 and troughs at zeitgeber time 12.
  • Vegf mRNA expression lacked a circadian rhythm during decidualization.
  • These findings suggest that cellular differentiation in uterine endometrial stromal cells interferes with circadian rhythms.

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