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The nuclear receptor REV-ERBαrepresses the transcription ofgrowth/differentiation factor 10and15genes in rat endometrium stromal cells
REV-ERBα reduces growth factor gene activity in rat uterine support cells
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Abstract
A significant decline of Per2-dLuc bioluminescence activity was observed in decidualized uterine endometrial stromal cells.
- Cellular oscillators in the uterus are linked to the regulation of Gdf10 and Gdf15 gene expression during decidualization.
- The expression of canonical clock genes decreased in decidualized uterine endometrial stromal cells.
- Upregulation of Gdf10 and Gdf15 occurs alongside the downregulation of REV-ERBα when Bmal1 is silenced.
- Gdf5, Gdf7, and Gdf11 showed no significant changes in expression following Bmal1 silencing.
- Treatment with a REV-ERBα antagonist increased the expression of Gdf10 and Gdf15, regardless of progesterone presence.
- REV-ERBα inhibits Gdf10 and Gdf15 expression by binding to their gene promoters in uterine endometrial stromal cells.
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