Circadian Clock-Specific Roles for the Light Response Protein WHITE COLLAR-2

The wc-2 allele ER24 contains a mutation that results in a lengthened circadian clock period.

• The mutation in wc-2 ER24 leads to reduced levels of important clock gene products, frq mRNA and FRQ protein.
• Temperature increases cause a significant decrease in period length, indicating a defect in temperature compensation.
• As temperature rises, overall FRQ protein levels increase, with a more substantial increase observed in the wc-2 (ER24) allele compared to wild type.
• Overall frq mRNA levels remain largely unchanged with temperature variation.
• The normal function of WC-2 is essential for regulating period length and temperature response in the circadian clock.

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