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Alternative Use of DNA Binding Domains by the Neurospora White Collar Complex Dictates Circadian Regulation and Light Responses
How Different DNA Binding Choices by the Neurospora White Collar Complex Control the Body Clock and Light Responses
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Abstract
The DBD region of WC-1 is essential for both DNA binding and interactions with the FRQ-FRH complex.
- The White Collar complex (WCC) drives the transcription of the circadian pacemaker gene frequency (frq).
- FRQ, part of the FRQ-FRH complex, inhibits its own expression.
- Light induction of frq is mediated by WCC binding to gene promoters, resetting the circadian clock.
- Not all light-induced genes are regulated by the circadian clock, and vice versa.
- DNA binding for light induction requires only WC-2, while circadian functions necessitate both WC-2 and specific motifs from WC-1.
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