Full text is available at the source.
The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats
The daily rhythm protein PER1 helps control blood vessel signals in salt-sensitive rats
AI simplified
Abstract
In Dahl salt-sensitive rats, increased renal endothelin-1 peptide levels were observed compared to control rats.
- Higher levels of endothelin-1 peptide were found in the kidneys of salt-sensitive rats.
- Gene expression related to the endothelin axis was altered in various tissues such as the kidney, adrenal glands, and liver.
- The expression of an antisense long non-coding RNA, linked to the circadian clock gene PER1, was also changed in salt-sensitive rats.
- These findings suggest that the circadian clock gene PER1 may act as a negative regulator of the endothelin axis.
AI simplified