Full text is available at the source.
Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment
Removing the body clock protein PER1 changes ET-1 levels differently in male and female mice after high salt and hormone treatment
AI simplified
Abstract
Male global PER1 knockout mice show a decreased night/day ratio of urinary endothelin-1 (ET-1).
- Significant differences in ET-1 and its receptor expression were observed in male PER1 knockout mice but not in females when subjected to a high-salt diet plus mineralocorticoid treatment.
- Both male wild-type and global PER1 knockout mice significantly increased endothelin B receptor expression in response to the treatment, while female mice did not.
- Knockdown of PER1 in mouse kidney cells led to increased ET-1 mRNA expression and peptide secretion upon aldosterone treatment.
- PER1 may serve as a negative regulator of ET-1 expression in the context of high-salt diet and mineralocorticoid treatment.
AI simplified