Desoxycorticosterone pivalate‐salt treatment leads to non‐dipping hypertension in Per1 knockout mice

Per1 knockout mice exhibited significantly increased mean arterial pressure in response to a high salt diet plus mineralocorticoid.

• Wild-type mice showed no change in blood pressure when subjected to a high salt diet plus mineralocorticoid.
• Per1 knockout mice lost the expected decrease in blood pressure during the inactive phase compared to the active phase.
• The high salt diet plus mineralocorticoid treatment resulted in a non-dipper phenotype in Per1 knockout mice.
• These findings suggest that the circadian clock protein PER1 may play a critical role in blood pressure regulation under high salt conditions.

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