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Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse
Missing the serotonin transporter does not stop hormone-related high blood pressure in rats and mice
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Abstract
Mean arterial blood pressure increased similarly by approximately 50 mm Hg in both wild type and serotonin transporter knockout models given DOCA and salt.
- No significant difference in basal blood pressure was observed between wild type and serotonin transporter knockout mice.
- The absence of a functional serotonin transporter did not affect the development of DOCA-salt induced hypertension.
- Overall, both wild type and knockout strains exhibited similar responses to DOCA and salt treatment.
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