Missing the serotonin transporter does not stop hormone-related high blood pressure in rats and mice

Mean arterial blood pressure increased similarly by approximately 50 mm Hg in both wild type and serotonin transporter knockout models given DOCA and salt.

• No significant difference in basal blood pressure was observed between wild type and serotonin transporter knockout mice.
• The absence of a functional serotonin transporter did not affect the development of DOCA-salt induced hypertension.
• Overall, both wild type and knockout strains exhibited similar responses to DOCA and salt treatment.

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