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Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats
Removing the Body Clock Protein PER1 May Worsen High Blood Pressure and Kidney Damage in Salt-Sensitive Rats
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Abstract
Loss of PER1 in Dahl salt-sensitive rats is associated with worsened salt-sensitive hypertension and renal damage.
- Male Dahl salt-sensitive rats with a global knockout of PER1 developed hypertension after three weeks on a high-salt diet.
- These rats showed increased variability in mean arterial pressure rhythms despite being kept on a normal light:dark cycle.
- Sodium excretion decreased in the rats on the high-salt diet.
- Creatinine clearance, an indicator of renal function, was reduced in these rats.
- Higher plasma aldosterone levels were observed in the salt-sensitive rats, indicating altered hormonal responses.
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