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Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II–Dependent Hypertension in Mice
Low-Salt Diet and Disrupted Body Clock Together Increase Blood Pressure Through Angiotensin II in Mice
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Abstract
Administration of angiotensin II resulted in nondipping blood pressure and increased vascular hypertrophy in specific genetically modified mice.
- Circadian rhythms in blood pressure can be disrupted by factors such as hypertension and sleep apnea.
- Period isoform knockout mice showed exacerbated blood pressure issues and vascular changes compared to wild-type mice after angiotensin II treatment.
- A low-salt diet decreased blood pressure in wild-type mice but led to a loss of circadian rhythm in blood pressure for Period isoform knockout mice.
- The increase in resting blood pressure in knockout mice could be restored to a rhythmic pattern with angiotensin receptor blocker losartan.
- Chronic low-salt diet contributed to vascular hypertrophy in Period isoform knockout mice, along with increased renin levels and changes in angiotensin receptor expression.
- Circadian clock genes may influence how the body responds to sodium restriction, potentially affecting nighttime blood pressure regulation.
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