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Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention
Removing endothelin B receptors in kidney salt-collecting cells may cause high blood pressure and salt buildup
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Abstract
CD ETB receptor knockout mice displayed elevated blood pressure, particularly during high-salt feeding.
- Systolic blood pressure was increased in mice lacking the CD ETB receptor on both normal and high-salt diets.
- CD ETB KO mice experienced lower hypertension compared to CD ET-1 KO mice, indicating differing roles of these receptors.
- Impaired sodium excretion was observed in CD ETB KO mice following acute sodium loading.
- Decreased levels of aldosterone and plasma renin activity were noted in CD ETB KO mice regardless of dietary sodium intake.
- Plasma and urinary ET-1 levels remained unchanged in CD ETB KO mice compared to controls.
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