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Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality
Removing endothelin-1 from urine-concentrating cells changes how vasopressin controls urine concentration
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Abstract
CD ET-1 KO mice showed reduced plasma vasopressin concentration and increased renal sensitivity to vasopressin's effects.
- Endothelin-1 (ET-1) in the collecting duct may inhibit the action of vasopressin (AVP) on water permeability.
- Urinary osmolality, plasma sodium concentration, urine volume, and renal aquaporin-2 levels remained unchanged during normal water intake in CD ET-1 KO mice.
- CD ET-1 KO mice exhibited impaired ability to excrete an acute water load, indicating a disruption in renal water regulation.
- In CD ET-1 KO mice, there was an increase in urinary osmolality and aquaporin-2 levels in response to vasopressin infusion.
- Elevated cAMP accumulation was observed in collecting duct suspensions from CD ET-1 KO mice following stimulation with vasopressin and forskolin.
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