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How the blood pressure system affects hormone control from kidney tubules
Updated
Abstract
Knockout of endothelin-1 in renal collecting ducts leads to hypertension and impaired sodium excretion.
- Renal renin content remains similar between knockout and control mice under normal sodium intake.
- High sodium intake reduces renal renin content equally in both knockout and control mice.
- Plasma renin concentrations reflect changes in renal renin content.
- Angiotensin receptor blocker valsartan normalizes blood pressure in knockout mice during normal sodium intake.
- High sodium intake combined with angiotensin receptor blocker treatment increases blood pressure only in knockout mice.
- Aldosterone antagonist spironolactone also normalizes blood pressure in knockout mice during normal sodium intake.
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