Role of the renin–angiotensin–aldosterone system in collecting duct-derived endothelin-1 regulation of blood pressureThis article is one of a selection of papers published in the special issue (part 1 of 2) on Forefronts in Endothelin.

Knockout of endothelin-1 in renal collecting ducts leads to hypertension and impaired sodium excretion.

• Renal renin content remains similar between knockout and control mice under normal sodium intake.
• High sodium intake reduces renal renin content equally in both knockout and control mice.
• Plasma renin concentrations reflect changes in renal renin content.
• Angiotensin receptor blocker valsartan normalizes blood pressure in knockout mice during normal sodium intake.
• High sodium intake combined with angiotensin receptor blocker treatment increases blood pressure only in knockout mice.
• Aldosterone antagonist spironolactone also normalizes blood pressure in knockout mice during normal sodium intake.

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