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High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETBreceptor expression
High salt increases ET-1’s self-activating effect to boost nitric oxide in kidney’s inner collecting duct by raising ETB receptor levels
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Abstract
After 7 days of a high-salt diet, there was a twofold increase in nitrite production in the inner medullary collecting duct (IMCD).
- ET-1, ETB receptor, and nitric oxide synthase-1 pathways are important for managing fluid and electrolyte balance during high-salt intake.
- Increased ETB expression to 100% was observed in IMCDs after high-salt feeding.
- Blockade of the ETB receptor prevented the increase in ion transport inhibition in primary IMCDs.
- Nitrite production in IMCD was similarly elevated in vascular endothelial ET-1 knockout and control mice after high-salt feeding.
- However, nitric oxide production in IMCD from collecting duct ET-1 knockout mice was significantly reduced during high-salt feeding.
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