Effect of mineralocorticoid treatment in mice with collecting duct-specific knockout of endothelin-1

CD ET-1 knockout mice exhibited substantially higher blood pressure and fluid retention compared to controls on a high-salt diet.

• Aldosterone increases blood pressure by promoting sodium reabsorption in the kidneys.
• Endothelin-1 produced in the collecting duct acts as a negative feedback mechanism to inhibit sodium reabsorption.
• CD ET-1 knockout mice showed increased consumption of high-salt diet and saline, as well as greater urine output.
• These knockout mice demonstrated elevated blood pressure and body weight when placed on a high-salt diet.
• Treatment with desoxycorticosterone pivalate further increased blood pressure in the CD ET-1 knockout mice.
• The absence of local endothelin-1 led to abnormal handling of fluids and electrolytes under high-salt conditions.

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